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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1983-12-17
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pubmed:abstractText |
Lipid A, the toxic moiety of Gram-negative bacterial lipopolysaccharides (endotoxins), is a glucosamine disaccharide to which fatty acid and phosphate residues are covalently attached. Recent studies of Salmonella lipid A indicate that 3-hydroxytetradecanoic acid (3-OH-14:0) residues are directly linked to the glucosamine backbone and the nonhydroxylated fatty acids (principally dodecanoic and tetradecanoic acids) are esterified to the hydroxyl groups of some of the 3-OH-14:0 molecules. We report here that the granule fraction of human neutrophils contains one or more enzymes that partially deacylate Salmonella typhimurium lipid A by removing the nonhydroxylated fatty acids, leaving almost all of the 3-OH-14:0 residues linked to glucosamine. The available evidence suggests that similar reactions also occur in living neutrophils that ingest lipopolysaccharides by antibody-dependent phagocytosis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-1163783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-376523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-387612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-4179068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-4560906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-4868364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-4889150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-4920244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-4983096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-5804498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-6061737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-6286756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-6749846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-6994199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-7000751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-7084225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-7285019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6356132-98070
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6671-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Enzymatic deacylation of the lipid A moiety of Salmonella typhimurium lipopolysaccharides by human neutrophils.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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