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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1983-12-17
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pubmed:abstractText |
Twenty-five patients with evaluable histologically confirmed inoperable metastatic sarcomas were treated once every four weeks with cyclophosphamide, doxorubicin, and cisplatin in doses of 400, 40, and 60 mg/m2, respectively. Cyclophosphamide and doxorubicin were given by rapid intravenous injection followed immediately by cisplatin by slow intravenous infusion (2-6 hr) in 1 liter of 0.45% saline with mannitol added. Leukopenia, alopecia, and vomiting were common side effects and three patients refused further treatment because of vomiting following their initial courses. No drug-related deaths occurred and we removed no one from the study because of toxicity problems. Among the 9 patients who experienced objective tumor regression were 2 of 2 with hemangiosarcoma, 3 of 5 with malignant fibrous histiocytoma, 3 of 5 with osteosarcoma, and 1 of 1 with pleomorphic liposarcoma of bone. Although not therapeutically gratifying, these results appear to be better than any previously observed at our institution.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0098-1532
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
319-21
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:6355797-Adolescent,
pubmed-meshheading:6355797-Adult,
pubmed-meshheading:6355797-Aged,
pubmed-meshheading:6355797-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:6355797-Cisplatin,
pubmed-meshheading:6355797-Clinical Trials as Topic,
pubmed-meshheading:6355797-Cyclophosphamide,
pubmed-meshheading:6355797-Doxorubicin,
pubmed-meshheading:6355797-Female,
pubmed-meshheading:6355797-Humans,
pubmed-meshheading:6355797-Male,
pubmed-meshheading:6355797-Middle Aged,
pubmed-meshheading:6355797-Sarcoma
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pubmed:year |
1983
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pubmed:articleTitle |
Cyclophosphamide, doxorubicin, and cisplatin combined in the treatment of advanced sarcomas.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
|