Linked Life Data

6355056

Source:http://linkedlifedata.com/resource/pubmed/id/6355056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-12-20
pubmed:abstractText
The efficacy of topical acyclovir in the treatment of herpes labialis has been evaluated in placebo-controlled trials with both the polyethylene glycol ointment and modified aqueous cream base preparations. Whereas a significant antiviral effect was demonstrated with acyclovir ointment in the two larger studies only favourable trends were demonstrated in the clinical parameters following early initiation of therapy. Significant clinical benefit was observed in a small single-centre study involving patients with frequent and generally more severe episodes of herpes labialis. In an animal model of experimental cutaneous herpes simplex virus infection acyclovir cream was found to be more effective than the ointment. This was confirmed in the first completed trial with acyclovir cream where a significant treatment effect was revealed on lesion duration and the inhibition of lesion development. Both topical preparations of acyclovir were well tolerated but acyclovir cream is to be preferred for the treatment of herpes labialis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
12 Suppl B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-103
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Acyclovir in the management of herpes labialis.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Review