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rdf:type |
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lifeskim:mentions |
umls-concept:C0005149,
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C0205409,
umls-concept:C0206664,
umls-concept:C0678594,
umls-concept:C2911684
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pubmed:issue |
7
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pubmed:dateCreated |
1983-12-20
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pubmed:databankReference |
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pubmed:abstractText |
Mouse teratocarcinoma cells express neither H-2 heavy chains nor beta 2-microglobulin (beta 2-m). We have constructed two genomic libraries, one from PCC4-aza-RI embryonal carcinoma cells and the other from their adult syngenic counterpart 129/Sv liver cells (H-2bc). The libraries were screened with a full length mouse beta 2-m cDNA probe which we isolated and sequenced. Two cosmid clones carrying the entire beta 2-m gene were isolated, one from each library. There was no detectable difference in structure between the two genes. Furthermore, both were shown to be active and to restore beta 2-m synthesis upon transfer into mutant cells deficient in beta 2-m. Irreversible DNA alterations in or around the beta 2-m gene are thus unlikely to account for the lack of beta 2-m gene expression in embryonal teratocarcinoma cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-14206435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-161604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-319344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-356353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-361082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-386835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-4200179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-4439455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-4599372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6170985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6171732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6171820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6174872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6180834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6260575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6264595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6276764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6298749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-63168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-6997135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-82601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6354707-91168
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1061-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Structure and expression of the mouse beta 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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