Linked Life Data

6354163

Source:http://linkedlifedata.com/resource/pubmed/id/6354163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Mechanical and cellular factors which maintain sterility in the fallopian tube were studied in virgin, BALB/c mice. Quantitative cultures of homogenates from ovary/periovarian sac, fallopian tube and uterine horn were obtained at various times after intratubal injection of 6 X 10(7) Escherichia coli (E. coli) by micropuncture. Immediately post-injection, significantly higher bacterial counts were obtained from fallopian tube than from uterine horn, indicating a functional barrier at the uterotubal junction. Viable E. coli were usually absent from the genital tract within 7 days. Reduction in bacterial counts was significant at 24 h post-injection. Ligation of the uterine horn and/or induction of leucopenia prior to injection were associated with decreased bacterial clearance at 24 h. Histology of samples from normal, injected mice revealed marked polymorphonuclear leucocyte (PMNL) infiltration in response to E. coli, confirmed by quantitation of intralumenal PMNL. By 72 h post-injection, viable E. coli and PMNL containing phagocytosed particles were prominent in vaginal washings. No inflammatory response was elicited in leucopenic mice. We conclude that clearance of E. coli from the fallopian tube depends primarily on excretion through the lower genital tract and PMNL-associated bacterial activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0004-945X
pubmed:author
pubmed:issnType
Print
pubmed:volume
61 (Pt 3)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-99
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Host defences in the upper genital tract of the female: studies in a murine system.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't