| pubmed-article:6353674 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C0001942 | lld:lifeskim |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C0008161 | lld:lifeskim |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C0045268 | lld:lifeskim |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:6353674 | lifeskim:mentions | umls-concept:C0077034 | lld:lifeskim |
| pubmed-article:6353674 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:6353674 | pubmed:dateCreated | 1983-11-23 | lld:pubmed |
| pubmed-article:6353674 | pubmed:abstractText | Both chloral hydrate and trichloroethanol inhibited mouse liver alcohol dehydrogenase (LADH) in vitro. The inhibition of LADH by chloral hydrate appears to be non-competitive in nature with an inhibition constant (Ki) of about 2.7 X 10(-4) M. The inhibition of LADH by trichloroethanol was competitive and the (Ki) was about 2.7 X 10(-5) M. The elimination of ethanol from the blood and brain was significantly reduced in chloral hydrate- or trichloroethanol-pretreated mice. Since reduced elimination of ethanol could result in the prolongation of its central depressant activity, we suggest that this should be considered as a factor in the enhanced pharmacological effects of ethanol-chloral hydrate mixtures. | lld:pubmed |
| pubmed-article:6353674 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6353674 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6353674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6353674 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6353674 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6353674 | pubmed:issn | 0378-4274 | lld:pubmed |
| pubmed-article:6353674 | pubmed:author | pubmed-author:SharkawiMM | lld:pubmed |
| pubmed-article:6353674 | pubmed:author | pubmed-author:De Saint... | lld:pubmed |
| pubmed-article:6353674 | pubmed:author | pubmed-author:ElfassyBB | lld:pubmed |
| pubmed-article:6353674 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6353674 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:6353674 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6353674 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6353674 | pubmed:pagination | 321-8 | lld:pubmed |
| pubmed-article:6353674 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
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| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:meshHeading | pubmed-meshheading:6353674-... | lld:pubmed |
| pubmed-article:6353674 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6353674 | pubmed:articleTitle | Inhibition of alcohol dehydrogenase by chloral hydrate and trichloroethanol: possible role in the chloral hydrate-ethanol interaction. | lld:pubmed |
| pubmed-article:6353674 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6353674 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
