Linked Life Data

6353163

Source:http://linkedlifedata.com/resource/pubmed/id/6353163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-11-23
pubmed:abstractText
The uidA and uxuAB operons are each under the dual control of two repressor molecules: the uidR and uxuR encoded repressors negatively control the uidA operon whereas the uxuAB operon is regulated by the uxuR and exuR gene products. Plasmids overproducing the regulatory molecules encoded by exuR, uxuR, or uidR were used to investigate the regulation of these two operons. Large amounts of either exuR or uxuR repressor caused a complete repression of the uxuAB operon in exuR and uxuR double-deleted mutants, suggesting that the two repressors, when they are overproduced, are totally interchangeable for the control of the uxuAB operon. In contrast, the UxuR molecule has no effect on the other exu regulon operons controlled by the exuR gene product. The uidR and uxuR gene products appear to be partially interchangeable for the regulation of the uidA gene since addition of multicopy plasmids bearing uidR+, in uxuR deleted mutant strains, only partially suppresses the derepression of the uidA gene. Inversely, multicopies of uidR weakly reduced the synthesis of the uxuB gene product in uxuR derepressed mutants. The restrictions placed by these phenomena on the formulation of the mechanism of cooperation between the two repressor molecules for repressing the uxuAB and uidA operons are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0026-8925
pubmed:author
pubmed:issnType
Print
pubmed:volume
191
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Interchangeability of repressors for the control of the uxu and uid operons in E. coli K12.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't