Linked Life Data

6351965

Source:http://linkedlifedata.com/resource/pubmed/id/6351965

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Pieces of cortex cerebri anlage were dissected out from 16- to 17-day-old fetuses and transplanted to the cortical and cerebellar regions of 5- to 6-day-old rat pups. Twelve animals with grafts in the cortical region and 5 animals with grafts in the cerebellar region were studied 1.5-4 months later. Cresyl violet stained sections revealed no gross difference in either cell morphology, cell density or cell distribution between grafts in the two locations. A molecular layer-like zone was present on all free surfaces of the grafts, whether facing a ventricle or the meninges. The astrocytic development was studied using immunohistochemistry with antibodies against glial fibrillary acidic protein, (GFA), and the S-100 protein. Both antibodies visualized starshaped astrocytes and perivascular membranes surrounding blood vessels. Semi-quantitative measurements as well as computerized image analysis showed that the total amount of GFA-like immunoreactivity was much higher in both types of grafts than in corresponding host cortex cerebri. No differences in amount of S-100-like immunoreactivity could be demonstrated. As S-100 is thought to be a more general astrocytic marker than GFA, this suggests that the difference in GFA-like immunoreactivity is due mainly to an increased amount of GFA within the individual astrocytes. It is concluded that grafts of fetal cortex cerebri pieces to the CNS of young hosts develop a profound astrocytic reaction characterized by an increased amount of GFA-like immunoreactivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Astrocytic development in fetal parietal cortex grafted to cerebral and cerebellar cortex of immature rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't