Linked Life Data

6351858

Source:http://linkedlifedata.com/resource/pubmed/id/6351858

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-10-28
pubmed:abstractText
Liver plasma membranes bind insulin in a complex fashion via three prominent disulfide-linked insulin receptor structures of 360K, 300K, and 260K molecular weight. To determine if the complex binding is explained by different binding affinities among the different structures, 125I-insulin was specifically cross-linked to the binding sites and the amount of radiolabeled insulin was determined after SDS-gel electrophoresis. The insulin binding characteristics of each structure were similar to the binding properties of the intact membrane. The Scatchard plot for each structure was curvilinear and the Kd values for the high and low affinity components were similar to the membrane values. Thus, the curvilinear Scatchard plot of insulin binding to liver membranes is also a feature of each receptor structure and is not a function of different receptors with different binding properties.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1042-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The different receptor species of liver have similar complex insulin binding properties.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.