Linked Life Data

6351533

Source:http://linkedlifedata.com/resource/pubmed/id/6351533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-10-21
pubmed:abstractText
Rat micropuncture experiments have been performed to investigate the influence of renal interstitial pressure conditions on proximal tubular fluid absorption and on the tubulo-glomerular feedback mechanism. The feedback mechanism works by sensing the distal tubular fluid flow rate at the macula densa segment and adjusting the tonus of the arterioles with resulting changes in blood flow and glomerular filtration rate. It was found that in situations with high hydrostatic and low oncotic pressure within the interstitium like in saline volume expansion and post-nephrectomy situations, proximal tubular fluid absorption and the sensitivity of the tubulo-glomerular feedback control are reduced giving rise to increased urine production without activating the feedback mechanism. In situations with low hydrostatic and high oncotic interstitial pressures like in dehydration, hypotension and hypovolemia proximal fluid absorption and feedback sensitivity is increased, feedback sensitivity even so much that the mechanism is activated to reduce GFR even though the load to the distal portion of the nephron is reduced below normal. In this way renal interstitial pressure-volume conditions can modulate renal function in response to extracellular fluid needs and blood pressure level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8843
pubmed:author
pubmed:issnType
Print
pubmed:volume
305
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-8
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Modulation of renal tubular function by renal interstitium.
pubmed:publicationType
Journal Article, Review