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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1983-10-21
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pubmed:abstractText |
Peripheral blood Ia-positive (Ia+) T cells were enumerated in 52 patients who had received allogeneic or syngeneic bone marrow transplantation for the treatment of acute leukemia or severe aplastic anemia. Twenty-two normal people showed 3 +/- 2% of peripheral blood T cells to be Ia+. During the first 130 days posttransplant, all patient groups showed a moderate elevation in the percentage (mean: 21-26%) of Ia+ T cells, regardless of the type of transplant performed, and regardless of the presence or absence of acute graft-versus-host disease (GVHD). Although there was marked individual variation (range 5-76%), there was a trend towards a decrease in the percentage of Ia+ T cells with increasing time after transplantation. Long-term survivors still showed a small (range 3-20%, mean 10%) but significant elevation in the relative number of Ia+ T cells 1-3.4 years after transplantation, regardless of the presence or absence of chronic GVHD. It is not currently known why Ia+ T cells are found in these patients, but accelerated lymphopoiesis, subclinical infection, and excessive immune stimulation caused by microorganisms or other foreign antigens could be contributing factors.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0041-1337
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-81
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6351369-Acute Disease,
pubmed-meshheading:6351369-Adult,
pubmed-meshheading:6351369-Anemia, Aplastic,
pubmed-meshheading:6351369-Bone Marrow Transplantation,
pubmed-meshheading:6351369-Graft vs Host Reaction,
pubmed-meshheading:6351369-Histocompatibility Antigens Class II,
pubmed-meshheading:6351369-Humans,
pubmed-meshheading:6351369-Leukemia,
pubmed-meshheading:6351369-Phenotype,
pubmed-meshheading:6351369-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Human T lymphocyte phenotypes after bone marrow transplantation. T cells expressing Ia-like antigen.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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