Linked Life Data

6351091

Source:http://linkedlifedata.com/resource/pubmed/id/6351091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-10-28
pubmed:abstractText
An in vitro leukocyte blastogenic assay was utilized to establish an in vitro correlate of cell-mediated immunity to Legionella pneumophila antigen with spleen cells from sensitized guinea pigs. Incubation of spleen cells from sensitized but not normal guinea pigs with graded amounts of killed whole cell Legionella bacteria or sonicate derived from the bacteria resulted in an antigen-induced blast cell proliferation as evidenced by an increased uptake of [3H]-thymidine into spleen cell cultures. Peak responses occurred approximately 4-6 days after incubation of the spleen cells with antigen. Sensitivity of spleen cells from animals immunized with Legionella vaccine in adjuvant persisted for at least 150 days, while responses after infection of guinea pigs with viable bacteria persisted about 4-6 weeks. The blastogenic responses of the spleen cells to Legionella antigen appeared to be a correlate of cell-mediated immunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
173
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-52
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Blastogenic responsiveness of spleen cells from guinea pigs sensitized to Legionella pneumophila antigens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.