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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1983-10-28
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pubmed:abstractText |
A recently proposed approach for spatial structure determination in noncrystalline proteins by nuclear magnetic resonance was applied to the lac repressor DNA-binding domain. On the basis of sequence-specific 1H NMR assignments, the location of alpha-helices in the amino acid sequence was determined from nuclear Overhauser enhancement data and from amide proton exchange studies. These investigations provide detailed experimental data on the structure of a noncrystalline DNA-binding protein. The results support the hypothesis advanced by others that sequence-specific interactions between lac repressor and DNA are mediated by a particular spatial arrangement of two alpha-helices common to various different DNA-binding proteins.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-231106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-321012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-365582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-372550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-385890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-5333290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6176717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6184480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6212926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6213863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6260218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6261152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6338916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6452580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6673752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6759662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6759663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6896364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6897114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6933550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-6951187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7011373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7011374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7015809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7030383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7043455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7077675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7077676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7077677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7088190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7143444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7213616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7236292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7260038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-7260039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6351066-779429
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5837-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Secondary structure of the lac repressor DNA-binding domain by two-dimensional 1H nuclear magnetic resonance in solution.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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