Linked Life Data

6350845

Source:http://linkedlifedata.com/resource/pubmed/id/6350845

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-10-28
pubmed:abstractText
Natural aromatic heptaene macrolide antibiotics and their N-acyl and methyl ester derivatives, which differ mainly in their electric net charge, were compared for their efficiency in inducing yeast growth inhibition, red blood cell lysis, and increase in the ionic permeability of large unilamellar lipidic vesicles. Antifungal activity was found to decrease in the following order: neutral congruent to positively charged greater than negatively charged compounds. Hemolytic activity decreased in the order: neutral greater than negatively charged much greater than positively charged compounds. On lipidic model membranes, themselves either positively or negatively charged, electrostatic interaction was shown to have practically no influence on the efficiency of the differently charged antibiotics. On both biological and model systems, positively charged antibiotics consistently were found to be more active on ergosterol-containing than on cholesterol-containing membranes, and were therefore considered as potentially good candidates for specific antifungal agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0026-895X
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
270-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The influence of electric charge of aromatic heptaene macrolide antibiotics on their activity on biological and lipidic model membranes.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't