Linked Life Data

6347548

Source:http://linkedlifedata.com/resource/pubmed/id/6347548

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-9-23
pubmed:abstractText
Bacterial growth kinetics and checkerboard titration experiments have been performed to determine the inhibitory power of metioprim (I) and brodimoprim (II) alone and in combination with diaminodiphenylsulfone (DDS) using Escherichia coli and mycobacteria as test organisms. The evaluated potency of the new TMP derivatives alone and in combination is compared to TMP and other derivatives. A strongly synergistic activity of I and II in combination with DDS against E. coli and various mycobacteria is observed which is also operative in case of highly DDS-resistant mycobacterial strains. The implication of these findings for the development of a combined chemotherapy with these drugs against atypical mycobacterial infections - especially leprosy - is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0009-3157
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-61
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI).
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't