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rdf:type |
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lifeskim:mentions |
umls-concept:C0019944,
umls-concept:C0021403,
umls-concept:C0042210,
umls-concept:C0178602,
umls-concept:C0205473,
umls-concept:C0441800,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2603343,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
1983-8-26
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pubmed:abstractText |
Serological responses to three bivalent aqueous equine influenza vaccines of different potency and an adjuvanted bivalent vaccine containing inactivated A/equine/Prague/56 (H7N7) and A/equine/Miami/63 (H3N8) viruses, were examined in seronegative ponies. Potencies of the vaccines, measured by single-radial-diffusion tests, ranged from 4 to 56 micrograms of haemagglutinin (HA) antigen activity/virus strain per dose. Serological responses to vaccination were examined by haemagglutination-inhibition (HI) and single-radial-haemolysis (SRH) tests. Four weeks after a primary dose, HI responses to both vaccine viruses were barely detectable; after a second dose the HI responses to A/Miami/63 virus were low or undetectable but HI responses to A/Prague/56 virus were higher (17/20 ponies with titres greater than or equal to 1:16). In contrast SRH tests revealed dose-related antibody responses to both virus strains after one and two vaccine doses; levels after the second dose were 2- to 5-fold higher than after the primary dose. Highest post-vaccination antibody titres were obtained with the adjuvanted vaccine which contained 2- to 4-fold less antigen (13-23 micrograms HA) than the most potent aqueous vaccine. Post-vaccination antibody reacted well in SRH tests with recent antigenic variants of equine influenza virus. A remarkable finding was the high rate of decline in antibody, detected by HI or SRH tests, following one or two doses of vaccine. Even in animals with the highest post-vaccine antibody levels 2-4 weeks after a booster dose, antibody levels had declined to low or indetectable levels 14 weeks later. The low antibody titres detected at 14-32 weeks after vaccination were nevertheless vaccine dose-related.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-105040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-1082381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-13533033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-14058775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-14077956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-408355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-4285503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-4540996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-4826197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-604107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-604109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-604118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-6167660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-6275599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-6306098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-6995458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-7040463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-7245173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-806658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6345659-816480
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1724
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
371-84
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:6345659-Animals,
pubmed-meshheading:6345659-Antibodies, Viral,
pubmed-meshheading:6345659-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6345659-Hemagglutination Inhibition Tests,
pubmed-meshheading:6345659-Hemolytic Plaque Technique,
pubmed-meshheading:6345659-Horses,
pubmed-meshheading:6345659-Immunization, Secondary,
pubmed-meshheading:6345659-Influenza A virus,
pubmed-meshheading:6345659-Time Factors,
pubmed-meshheading:6345659-Vaccination,
pubmed-meshheading:6345659-Viral Vaccines
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pubmed:year |
1983
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pubmed:articleTitle |
Studies with inactivated equine influenza vaccine. 1. Serological responses of ponies to graded doses of vaccine.
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pubmed:publicationType |
Journal Article
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