Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1983-7-8
pubmed:abstractText
Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. At nanomolar concentrations the peptide markedly enhances the ability of fresh serum to stimulate DNA synthesis in confluent and quiescent cultures of these cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor; half-maximal effect is obtained at 1 nM. The mitogenic effect of bombesin is dependent on dose and time, is mimicked by litorin, and is markedly potentiated by insulin, colchicine, platelet-derived growth factor, and fibroblast-derived growth factor. These mitogens increase the maximal response elicited by bombesin and decrease the bombesin concentration required to produce half-maximal effect (from 1 nM to 0.3 nM). In contrast, vasopressin, phorbol esters, or cAMP increasing agents fail to enhance the maximal level of DNA synthesis induced by bombesin. Bombesin and litorin may provide useful model peptides for studies on the mechanism(s) by which extracellular ligands control cell proliferation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-1060129, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-1201380, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-13985244, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-188046, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-216015, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-281686, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-312501, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-351419, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-456618, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-456621, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-492336, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-496973, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-496992, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-5544731, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6117568, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6129025, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6159649, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6180890, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-618913, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6253509, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6254071, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6254731, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6256365, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6265069, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6267317, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6270677, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6272398, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6277944, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6282602, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6285381, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6286693, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6288743, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-642826, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6456922, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-656396, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6756540, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6799271, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6803796, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-6975480, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-7039258, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-7061703, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-7263691, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-7337035, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-7432481, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-743973, http://linkedlifedata.com/resource/pubmed/commentcorrection/6344074-84318
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2936-40
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.
pubmed:publicationType
Journal Article