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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
13
|
pubmed:dateCreated |
1978-5-24
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pubmed:abstractText |
EEG studies were done on patients with CNS disease who were treated with d-aldosterone and spirolactone. The baseline EEGs of these patients were found to be slightly abnormal. During infusion of the spirolactone derivative potassium canrenoate a transient deterioration of preexisting EEG disturbances was observed; in addition, bursts of increased muscle activity and transient relative bradycardia were seen. These findings indicate that potassium canrenoate or its lipophilic metabolite canrenone may affect the nervous system directly, possibly via a disturbance in the electrolyte balance. These results are compatible with recent findings in animal studies.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
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pubmed:issn |
0025-8458
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
31
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pubmed:volume |
73
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
470-3
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:634207-Aldosterone,
pubmed-meshheading:634207-Brain Edema,
pubmed-meshheading:634207-Canrenoate Potassium,
pubmed-meshheading:634207-Electroencephalography,
pubmed-meshheading:634207-Encephalitis,
pubmed-meshheading:634207-Female,
pubmed-meshheading:634207-Humans,
pubmed-meshheading:634207-Male,
pubmed-meshheading:634207-Multiple Sclerosis,
pubmed-meshheading:634207-Spironolactone
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pubmed:year |
1978
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pubmed:articleTitle |
[EEG changes following spirolactone treatment (author's transl)].
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pubmed:publicationType |
Journal Article,
English Abstract
|