Linked Life Data

6341265

Source:http://linkedlifedata.com/resource/pubmed/id/6341265

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-10
pubmed:abstractText
The induction of antibody formation mediated significant changes in circulating corticosterone (CS) levels in mice. On the day of the peak plaque-forming cell (PFC) response to sheep red blood cells (SRBC) or to the trinitrophenyl (TNP) hapten, the 0800 h serum CS concentration was increased. This hormonal elevation was not observed in SRBC-immunized low responder animals which did not give a significant PFC response, thus suggesting a direct correlation between immune responsiveness and hormonal changes. A change in the circadian rhythm of CS was evident in immune animals injected with SRBC. Control animals injected with saline showed a regular circadian pattern of low CS level at 0800 h followed by a high level at 1600 h. In contrast, responding animals injected with SRBC were found to have a reversed CS pattern, i.e. the hormonal concentration was high at 0800 h and low at 1600 h, on the day of the peak PFC response. This reversal of the circadian CS pattern may have important immunoregulatory significance. The immunization-induced CS response could be significantly blocked by the administration of diazepam (DZM), an effect which implies the involvement of central hypothalamic-pituitary control of the response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-0561
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-33
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Neuroendocrine regulation of immune processes: change in circulating corticosterone levels induced by the primary antibody response in mice.
pubmed:publicationType
Journal Article