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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1983-5-5
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pubmed:abstractText |
One hundred ten of 175 patients with aplastic anemia conditioned by cyclophosphamide had sustained engraftment of marrow from human leukocyte antigen (HLA)-identical siblings and lived for more than 6 months. Forty-nine of the 110 patients developed chronic graft-versus-host disease between 85 and 464 days. Ninety-seven patients are alive from 1.4 to 11 years after engraftment; 13 died between 208 and 726 days. Twenty of the 36 surviving patients with chronic graft-versus-host disease have Karnofsky performance scores of 100%, 7 of 90%, 5 of 80%, 1 of 70%, 2 of 60%, and 1 of 40%. Our analysis, using a binary logistic regression model, identified three factors predicting chronic graft-versus-host disease: moderate to severe acute graft-versus-host disease with an estimated relative risk of 11.65; increasing patient age; and the use of viable donor buffy coat cells in addition to the marrow to prevent graft rejection. The last two factors were significant only in patients without acute graft-versus-host disease.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
pubmed:issn |
0003-4819
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pubmed:author |
pubmed-author:AppelbaumF AFA,
pubmed-author:BucknerC DCD,
pubmed-author:CliftR ARA,
pubmed-author:DeegH JHJ,
pubmed-author:DoneyK CKC,
pubmed-author:PrenticeR LRL,
pubmed-author:SandersJ EJE,
pubmed-author:ShulmanH MHM,
pubmed-author:StewartP SPS,
pubmed-author:StorbRR,
pubmed-author:SullivanK MKM,
pubmed-author:ThomasE DED,
pubmed-author:WitherspoonR PRP
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
461-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6340576-Adolescent,
pubmed-meshheading:6340576-Adult,
pubmed-meshheading:6340576-Age Factors,
pubmed-meshheading:6340576-Anemia, Aplastic,
pubmed-meshheading:6340576-Bone Marrow Transplantation,
pubmed-meshheading:6340576-Child,
pubmed-meshheading:6340576-Child, Preschool,
pubmed-meshheading:6340576-Female,
pubmed-meshheading:6340576-Follow-Up Studies,
pubmed-meshheading:6340576-Graft vs Host Reaction,
pubmed-meshheading:6340576-HLA Antigens,
pubmed-meshheading:6340576-Humans,
pubmed-meshheading:6340576-Infant,
pubmed-meshheading:6340576-Male,
pubmed-meshheading:6340576-Postoperative Complications,
pubmed-meshheading:6340576-Risk
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pubmed:year |
1983
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pubmed:articleTitle |
Predictive factors in chronic graft-versus-host disease in patients with aplastic anemia treated by marrow transplantation from HLA-identical siblings.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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