Linked Life Data

6339724

Source:http://linkedlifedata.com/resource/pubmed/id/6339724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-5-27
pubmed:abstractText
A phosphonate analogue of pyridoxal 5'-phosphate containing a 5'-phosphonomethyl group and its monoethyl and diethyl esters have been prepared. Except for the diethyl ester, the compounds appear to bind into the active site of aspartate aminotransferase. However, they lack detectable catalytic activity with this enzyme and with glutamate decarboxylase of Escherichia coli. The phosphonomethyl analogue bound to aspartate aminotransferase does react slowly with substrates, as determined by spectrophotometric observations; the monomethyl ester reacts about 20 times less rapidly. Because of the stability of the phosphonate linkage, these compounds may be useful as modifying reagents for various proteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
595-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Phosphonate analogues of pyridoxal phosphate with shortened side chains.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.