| pubmed-article:6337907 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6337907 | lifeskim:mentions | umls-concept:C0022131 | lld:lifeskim |
| pubmed-article:6337907 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:6337907 | lifeskim:mentions | umls-concept:C0000578 | lld:lifeskim |
| pubmed-article:6337907 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:6337907 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6337907 | lifeskim:mentions | umls-concept:C1521805 | lld:lifeskim |
| pubmed-article:6337907 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6337907 | pubmed:dateCreated | 1983-4-21 | lld:pubmed |
| pubmed-article:6337907 | pubmed:abstractText | The effects of 5-hydroxytryptamine and 5-hydroxytryptophan on insulin release and 45Ca2+ uptake in islets microdissected from ob/ob mice were studied. At a concentration of 4 mmol/l both compounds slightly stimulated insulin release at a low glucose concentration (3 mmol/l). Insulin release induced by 20 mmol/l D-glucose was inhibited by 4 mmol/l 5-hydroxytryptamine but potentiated by 4 mmol/l L-5-hydroxytryptophan. Mannoheptulose (20 mmol/l) blocked the combined effects of 20 mmol/l D-glucose and 4 mmol/l L-5-hydroxytryptophan on insulin release. 45Ca2+ uptake was inhibited by 4 mmol/l 5-hydroxytryptamine and stimulated by 4 mmol/l L-5-hydroxytryptophan. Mannoheptulose (20 mmol/l) did not affect the 45Ca2+ uptake induced by the latter. When 4 mmol/l L-5-hydroxytryptophan was present only during the 30-min preincubation period. 20 mmol/l-glucose-induced insulin release and 45Ca2+ uptake during a subsequent incubation period were inhibited. Externally added 5-hydroxytryptamine (4 mmol/l) did not change the effects of 4 mmol/l L-5-hydroxytryptophan on insulin release and 45Ca2+ uptake. It is concluded that, when added directly into the incubation medium, 5-hydroxytryptophan has effects on insulin release and 45Ca2+ uptake which are opposite to those observed when 5-hydroxytryptamine is added. These effects do not seem to be mediated by 5-hydroxytryptamine formed intracellularly from 5-hydroxytryptophan. | lld:pubmed |
| pubmed-article:6337907 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6337907 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6337907 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6337907 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6337907 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6337907 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6337907 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6337907 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6337907 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6337907 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6337907 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6337907 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:6337907 | pubmed:author | pubmed-author:SehlinJJ | lld:pubmed |
| pubmed-article:6337907 | pubmed:author | pubmed-author:LindströmPP | lld:pubmed |
| pubmed-article:6337907 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6337907 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:6337907 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6337907 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6337907 | pubmed:pagination | 52-7 | lld:pubmed |
| pubmed-article:6337907 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:meshHeading | pubmed-meshheading:6337907-... | lld:pubmed |
| pubmed-article:6337907 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6337907 | pubmed:articleTitle | Opposite effects of 5-hydroxytryptophan and 5-hydroxytryptamine on the function of microdissected ob/ob-mouse pancreatic islets. | lld:pubmed |
| pubmed-article:6337907 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6337907 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6337907 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6337907 | lld:pubmed |
