Linked Life Data

6337907

Source:http://linkedlifedata.com/resource/pubmed/id/6337907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-4-21
pubmed:abstractText
The effects of 5-hydroxytryptamine and 5-hydroxytryptophan on insulin release and 45Ca2+ uptake in islets microdissected from ob/ob mice were studied. At a concentration of 4 mmol/l both compounds slightly stimulated insulin release at a low glucose concentration (3 mmol/l). Insulin release induced by 20 mmol/l D-glucose was inhibited by 4 mmol/l 5-hydroxytryptamine but potentiated by 4 mmol/l L-5-hydroxytryptophan. Mannoheptulose (20 mmol/l) blocked the combined effects of 20 mmol/l D-glucose and 4 mmol/l L-5-hydroxytryptophan on insulin release. 45Ca2+ uptake was inhibited by 4 mmol/l 5-hydroxytryptamine and stimulated by 4 mmol/l L-5-hydroxytryptophan. Mannoheptulose (20 mmol/l) did not affect the 45Ca2+ uptake induced by the latter. When 4 mmol/l L-5-hydroxytryptophan was present only during the 30-min preincubation period. 20 mmol/l-glucose-induced insulin release and 45Ca2+ uptake during a subsequent incubation period were inhibited. Externally added 5-hydroxytryptamine (4 mmol/l) did not change the effects of 4 mmol/l L-5-hydroxytryptophan on insulin release and 45Ca2+ uptake. It is concluded that, when added directly into the incubation medium, 5-hydroxytryptophan has effects on insulin release and 45Ca2+ uptake which are opposite to those observed when 5-hydroxytryptamine is added. These effects do not seem to be mediated by 5-hydroxytryptamine formed intracellularly from 5-hydroxytryptophan.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0012-186X
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Opposite effects of 5-hydroxytryptophan and 5-hydroxytryptamine on the function of microdissected ob/ob-mouse pancreatic islets.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't