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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1983-4-15
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pubmed:abstractText |
1 A double-blind trial with parallel treatment groups was conducted to compare the safety and efficacy of mianserin with amitriptyline. 2 This was a six week trial with weekly visits. Measurements at each visit included: 21 item Hamilton Depression (HAMD) Scale. Clinical Global Impression (CGI) Scale and Treatment Emergent Symptom Scale (TESS). 3 Mianserin and amitriptyline were comparable with respect to efficacy. 4 More adverse experiences were reported by amitriptyline patients. The predominant amitriptyline adverse experiences were of the anticholinergic type; the predominant mianserin adverse experience was drowsiness/fatigue. 5 The Efficacy Index (EI), a scale combining efficacy and adverse experiences, clearly demonstrated the superiority of mianserin over amitriptyline.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-27373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-341940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-341947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-341950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-354916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-360245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-375687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-385028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-393652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-623703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-6988172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-770364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-792861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-813949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337610-974442
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227S-237S
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6337610-Amitriptyline,
pubmed-meshheading:6337610-Clinical Trials as Topic,
pubmed-meshheading:6337610-Depressive Disorder,
pubmed-meshheading:6337610-Dibenzazepines,
pubmed-meshheading:6337610-Double-Blind Method,
pubmed-meshheading:6337610-Female,
pubmed-meshheading:6337610-Humans,
pubmed-meshheading:6337610-Male,
pubmed-meshheading:6337610-Mianserin,
pubmed-meshheading:6337610-Psychiatric Status Rating Scales,
pubmed-meshheading:6337610-Time Factors
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pubmed:year |
1983
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pubmed:articleTitle |
A double-blind comparative trial with mianserin and amitriptyline in outpatients with major depressive disorders.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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