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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
The possibility that fibronectin on the surface of oropharyngeal cells may serve as a receptor for the binding of group A streptococci (Streptococcus pyogenes) was investigated. Purified human plasma fibronectin inhibited the adherence of group A streptococci to oral epithelial cells in a dose-dependent manner. The relative amounts of fibronectin available on oral epithelial cells correlated closely with the ability of these cells to bind streptococci. Group A streptococci agglutinated latex beads containing covalently linked fibronectin on their surface, and this agglutination could be inhibited by lipoteichoic acid, the adhesion that mediates attachment of group A streptococci to epithelial cells. Gelatin and the alpha 1 chain of type I collagen partially inhibited both the adherence of streptococci to oral epithelial cells and the binding of radiolabeled fibronectin to streptococci; however, the purified fibronectin-binding peptide of collagen, alpha 1 (I)CB7, inhibited neither. The binding of radiolabeled fibronectin to streptococci was inhibited by lipoteichoic acid. These results suggest that fibronectin on oral epithelial cells serves as a lipoteichoic acid-sensitive receptor for group A streptococci.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-19499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-232521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-344328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-365905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-4899868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-534500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-650151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-6749687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-6788858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-6988694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-6989926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-6993465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-6998987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-7014444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-7014727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-7037070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-732875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-7403857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-7419572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-7447950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6337097-777026
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Adherence of group A streptococci to fibronectin on oral epithelial cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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