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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1983-3-17
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pubmed:abstractText |
Recent studies indicate that some peripheral noradrenergic nerves have specific 5-hydroxytryptamine (5-HT) receptors on their terminals that can mediate inhibition of release of transmitter after neuronal stimulation. It is now also known that 5-HT will cause norepinephrine release from noradrenergic nerve terminals in the isolated rabbit heart by a receptor mechanism. The evidence for the existence of these two types of prejunctional 5-HT receptor is discussed together with findings to date on their distribution and possible functional importance in the whole animal. In addition 5-HT has weak sympathomimetic actions, which result from its ability to interact with noradrenergic removal processes. The displaced transmitter can then interact with adrenoceptors situated pre- or postjunctionally.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0014-9446
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
218-22
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6337064-Animals,
pubmed-meshheading:6337064-Cardiovascular System,
pubmed-meshheading:6337064-Electric Stimulation,
pubmed-meshheading:6337064-Monoamine Oxidase,
pubmed-meshheading:6337064-Muscle, Smooth,
pubmed-meshheading:6337064-Neurons,
pubmed-meshheading:6337064-Norepinephrine,
pubmed-meshheading:6337064-Serotonin
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pubmed:year |
1983
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pubmed:articleTitle |
Prejunctional effects of 5-hydroxytryptamine on noradrenergic nerves in the cardiovascular system.
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pubmed:publicationType |
Journal Article,
Review
|