Linked Life Data

6336656

Source:http://linkedlifedata.com/resource/pubmed/id/6336656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-2-25
pubmed:abstractText
Cooxidation of xenobiotics may occur during prostaglandin biosynthesis. The ability of prostaglandin endoperoxide synthetase to cooxidize several aromatic amines and other chemicals to mutagenic products was tested with the standard Salmonella tester strains. The microsomal fraction of ram seminal vesicles, a rich source of prostaglandin endoperoxide synthetase, in the presence of the prostaglandin endoperoxide synthetase substrate arachidonic acid metabolized benzidine, 2-aminofluorene, 2-naphthylamine, and 2,5-diaminoanisole to mutagenic products. 1-Napthylamine, 2-aminoanthracene, 2-acetylaminofluorene, and 2,4-diaminoanisole were negative or weakly mutagenic. N-Nitrosodimethylamine, N-nitrosomorpholine, the pesticide Aminocarb, and di(2-ethylhexyl)phthalate were not activated to mutagenic products by the ram seminal vesicle microsomal fraction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
476-80
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Activation of some aromatic amines to mutagenic products by prostaglandin endoperoxide synthetase.
pubmed:publicationType
Journal Article