Linked Life Data

6335399

Source:http://linkedlifedata.com/resource/pubmed/id/6335399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1985-3-14
pubmed:abstractText
The effect of cefaclor (CCl) and other orally applied antibiotics were examined on different parameters of the immune response. It could be shown that CCl enhances specific IgM response in a dose dependent profile. This is dependent on the application time relative to immunization because it reduces the reaction if given thereafter. IgG response is inhibited in low but not in higher doses. Cellular immune reaction in CCl treated animals evaluated with the footpad swelling test shows also a dose dependent profile but it is always enhanced compared with controls. The cortisone or cyclophosphamide induced immunosuppression is largely abrogated. Prostaglandin E2 (PGE2) production by macrophages and PGE2-sensitivity of lymphocytes are rather reduced if cell donors were treated with CCl. Interleukin 1 production is clearly stimulated. The enhanced survival rate of CCl treated animals observed in experimental infections with the primary resistant Candida species is explained by the concomitant inhibition of PGE2-production as an inhibitor of immune reactions and reduction of PGE2-sensitivity together with a stimulation of cellular immunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1535-40
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Influence of cefaclor on immune response parameters.
pubmed:publicationType
Journal Article