Linked Life Data

6334856

Source:http://linkedlifedata.com/resource/pubmed/id/6334856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-2-4
pubmed:abstractText
Injection of 1,25 dihydroxycholecalciferol (1,25(OH)2D3, 10 micrograms) directly into the in situ ligated duodenal loop of rachitic chicks significantly elevated the tissue accumulation of 47Ca within 20-30 min. The transfer of 47Ca from lumen to blood, during the same time period, was not increased nor was there any measurable intestinal calcium-binding protein synthesized. Lesser amounts of 1,25(OH)2D3 (1 or 5 micrograms) did not result in any statistically significant elevation of 47Ca tissue accumulation, nor did they have any effect on 47Ca transfer from lumen to blood (transmural). Ten micrograms of 1,24R,25(OH)3D3 was similarly effective in elevating tissue accumulation, whereas 24R,25(OH)2D3 and 25(OH)D3 were not. These results provide additional evidence for an early and direct action of 1,25(OH)2D3 in altering intestinal epithelial membrane transport prior to the induction of synthesis of specific transport proteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
177
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Early and direct effect of 1,25-dihydroxycholecalciferol on calcium uptake by duodena of rachitic chicks.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.