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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1985-2-11
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pubmed:abstractText |
The relationship between HLA-DR antigens and various specific antinuclear antibodies was studied in 28 unselected black Americans with systemic lupus erythematosus (SLE). Anti-SSA(Ro) occurred with high frequency (61%) but was not associated with specific clinical features of SLE. HLA-DR7 was strongly associated with anti-SSA antibody; it was present in 13/17 patients with anti-SSA (76%) and 1/11 patients without it (9%). HLA-DR7 occurred in 14/28 of all SLE patients (50%) compared with 17% of 137 local controls (p corrected, less than 0.005). This association of HLA-DR7 with both susceptibility to SLE and a high frequency of anti-SSA antibody suggests a genetic link between the presence of anti-SSA antibody and susceptibility to SLE in the population studied.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antinuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR7 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Cytoplasmic,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/SS-A antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/SS-A antigen,
http://linkedlifedata.com/resource/pubmed/chemical/TROVE2 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
653-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6334744-Adolescent,
pubmed-meshheading:6334744-Adult,
pubmed-meshheading:6334744-African Continental Ancestry Group,
pubmed-meshheading:6334744-Aged,
pubmed-meshheading:6334744-Antibodies, Antinuclear,
pubmed-meshheading:6334744-Antigens,
pubmed-meshheading:6334744-Autoantigens,
pubmed-meshheading:6334744-Female,
pubmed-meshheading:6334744-Gene Frequency,
pubmed-meshheading:6334744-Genetic Markers,
pubmed-meshheading:6334744-HLA-DR Antigens,
pubmed-meshheading:6334744-HLA-DR7 Antigen,
pubmed-meshheading:6334744-Histocompatibility Antigens Class II,
pubmed-meshheading:6334744-Humans,
pubmed-meshheading:6334744-Lupus Erythematosus, Systemic,
pubmed-meshheading:6334744-Male,
pubmed-meshheading:6334744-Middle Aged,
pubmed-meshheading:6334744-RNA, Small Cytoplasmic,
pubmed-meshheading:6334744-Ribonucleoproteins,
pubmed-meshheading:6334744-Risk
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pubmed:year |
1984
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pubmed:articleTitle |
Association of HLA-DR7 with both antibody to SSA(Ro) and disease susceptibility in blacks with systemic lupus erythematosus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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