Linked Life Data

6332373

Source:http://linkedlifedata.com/resource/pubmed/id/6332373

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-10-1
pubmed:abstractText
Activation of T lymphocytes by an antigen requires joint recognition of the antigen and the class-II HLA determinants on the membrane of the antigen-presenting cells (APC). Patients with reactive arthritis exhibit a depressed lymphocyte transformation response to Yersinia, suggesting a possible immunoregulatory disturbance in these patients. In this study the role of Ia (class-II HLA antigen)-positive APC in the lymphocyte response to a complex antigen, whole Yersinia bacterium, was evaluated. The results demonstrate that Ia-positive cells are necessary for the T-lymphocyte response to Yersinia. The role of APC in the pathogenesis of reactive arthritis is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Role of Ia-positive cells in the lymphocyte responses to Yersinia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't