Linked Life Data

6332196

Source:http://linkedlifedata.com/resource/pubmed/id/6332196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1984-10-3
pubmed:abstractText
A series of peptides that contain an N-terminal 2-methyl-1,4-naphthoquinone group or analogues of this structure have been prepared as potential substrates or inhibitors of the rat liver microsomal vitamin K dependent carboxylase. The parent compound, gamma-2-(methyl-1,4-naphthoquinonyl-3)butyryl-Glu-Glu-Leu-OMe, is a good substrate for the carboxylase at low concentrations and has a Km of about 50 microM. This is roughly 2 orders of magnitude lower than the Km of most simple peptide substrates that have been synthesized. Replacement of the 2-methyl-1,4-naphthoquinone group with its desmethyl analogue, a naphthyl, or a stearyl group decreased substrate effectiveness. At higher concentrations, the parent compound and its desmethyl analogue were potent inhibitors of the vitamin K dependent carboxylation reaction. The degree of inhibition exhibited by these peptides was dependent on the vitamin KH2 concentration of the incubation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1196-201
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Derivatives of 2-methyl-1,4-naphthoquinone as substrates and inhibitors of the vitamin K dependent carboxylase.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't