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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1984-8-17
|
| pubmed:abstractText |
Mecillinam, an antibiotic of the beta-lactam group, is active against Gram negative bacilli, with the exception of a few species such as Haemophilus influenzae. The activities of ampicillin, mecillinam, and ampicillin-mecillinam combinations at ratios of 1/1, 2/1, 4/1, 1/2 and 1/4, on 21 Haemophilus influenzae strains, were studied by agar dilution and determination of minimal inhibitory concentrations (MIC). Ampicillin at concentrations of 0.12 to 0.25 mg/l was active on susceptible strains. Beta-lactamase-producing strains were inhibited by 4 and 8 mg/l ampicillin. MICs of mecillinam were above 128 mg/l for 19 strains; two strains were susceptible to 2 mg/l. In every case, antibacterial activity was greater with the ampicillin-mecillinam combination than with either one of the antibiotics alone. The maximum antibacterial effect was obtained at ratios of 1/1 and 1/2; in this case, susceptible strains were inhibited by 0.06 mg/l ampicillin. Kinetic evaluation (killing curves) showed that ampicillin has a bactericidal effect at concentrations under the MIC when it is combined with mecillinam at a 1/1 ratio.
|
| pubmed:language |
fre
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0369-8114
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
378-80
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1984
|
| pubmed:articleTitle |
[Inhibitory activity of ampicillin and mecillinam on Haemophilus influenzae].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|