Linked Life Data

6330482

Source:http://linkedlifedata.com/resource/pubmed/id/6330482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
1984-8-13
pubmed:abstractText
The effects of Friend virus infection on phosphatidylethanolamine methyltransferase, phosphatidylmonomethylethanolamine methyltransferase, phosphatidyldimethylethanolamine methyltransferase and choline phosphotransferase in mouse spleen microsomes were investigated 14 days following viral inoculation. There was a significant 9.2 fold increase above control values in the specific activity (pmol phosphatidylcholine formed/min/mg microsomal proteins) of choline phosphotransferase. No stimulation occurred in the activities of phosphatidylethanolamine methyltransferase, phosphatidylmonomethylethanolamine methyltransferase or phosphatidyldimethylethanolamine methyltransferase, the three enzymes involved in the methylation phosphatidylethanolamine (PE) to phosphatidylcholine (PC). The concentration of S-adenosylmethionine (AdoMet) and S-adenosylhomocysteine (AdoHcy), the substrate and physiological inhibitor of transmethylation reactions, respectively, were measured in the spleens of control and viral infected mice. AdoHcy is a competitive inhibitor of the phosphatidylethanolamine methyltransferase. A significant increase in the AdoHcy concentration and the resultant decrease in the AdoMet/AdoHcy ratio are sufficient to prevent stimulation of the transmethylation of PE to PC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2621-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effect of Friend virus infection on the biosynthetic enzymes of phosphatidylcholine biosynthesis in spleen microsomes.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't