Linked Life Data

6330225

Source:http://linkedlifedata.com/resource/pubmed/id/6330225

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl
pubmed:dateCreated
1984-8-13
pubmed:abstractText
Three mouse strains as well as wt and 7 ts mutants of herpes simplex virus (HSV) type 2 (strain HG52) have been used to investigate latency. The mice were inoculated in the right rear footpad. Virus reactivation following explanation and culture of the dorsal root ganglia and the footpad was scored. The results show that: HSV-2 can be maintained in the mouse footpad in a state indistinguishable from latency; virus gene functions necessary for latency can be identified by the use of ts mutants; and mouse strains differ in their ability to support latent infection. An infectious center assay was used to quantitate virus reactivation from dissociated dorsal root ganglia. HSV-1 strain 17 wt spread after inoculation at doses of greater than or equal to 5.0 X 10(5) plaque-forming units (pfu), producing latency also in contralateral ganglia but with lower efficiency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67s-71s
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Herpes simplex virus type 2 establishes latency in the mouse footpad and in the sensory ganglia.
pubmed:publicationType
Journal Article