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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1984-7-27
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pubmed:abstractText |
Excretion of herpes simplex virus (HSV) in the oral cavity was studied in eight human subjects with a history of herpes labialis. Serial intraoral specimens were obtained by gargling broth and examined for virus by centrifugal inoculation of primary human amnion cells. Forty-seven of 637 specimens (7.4%) contained HSV. The majority of isolates (62%) were found in clusters, and the rate of excretion was significantly increased during the common cold (21%) and after oral trauma (17%) (P = 0.001 and 0.04, respectively). Oral HSV excretion often occurred in parallel with episodes of herpes labialis but could not be attributed to viral contamination from a labial lesion. Each patient excreted only one strain of HSV type 1 as determined by restriction endonuclease analysis with KpnI and BamHI. Unexpectedly, prodromal symptoms of herpes labialis were commonly not followed by development of a lesion (false prodrome). False prodromes were associated with a high rate of oral HSV excretion (60%). Intraoral ulcers on the gingivae and hard palate were frequently associated with oral HSV excretion (31%) and are the most likely source of HSV in the oral cavity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-13073293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-14890831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-193008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-194157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-213385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-216753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-280847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-390063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-4290539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-4306748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-4311429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-4312871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-4317877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-6253776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-6255914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-6278068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-6279692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-6296239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-701851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-7045255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6330166-86158
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
675-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6330166-Adult,
pubmed-meshheading:6330166-DNA, Viral,
pubmed-meshheading:6330166-DNA Restriction Enzymes,
pubmed-meshheading:6330166-Female,
pubmed-meshheading:6330166-Herpes Labialis,
pubmed-meshheading:6330166-Humans,
pubmed-meshheading:6330166-Life Change Events,
pubmed-meshheading:6330166-Male,
pubmed-meshheading:6330166-Middle Aged,
pubmed-meshheading:6330166-Mouth,
pubmed-meshheading:6330166-Simplexvirus,
pubmed-meshheading:6330166-Stomatitis, Herpetic
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pubmed:year |
1984
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pubmed:articleTitle |
Pathogenesis of herpes simplex labialis: excretion of virus in the oral cavity.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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