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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
13
|
pubmed:dateCreated |
1984-8-20
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pubmed:abstractText |
The human neuroblastoma cell line T98G is sensitive to the antiproliferative activity of both alpha- and gamma-interferons (IFNs). Specific binding of a homogeneous 125I-IFN-alpha 2 probe to high-affinity membrane receptors (apparent Kd = 6.2 X 10(-10) M) can be decreased by pretreatment of these cells with human IFN-gamma (HuIFN-gamma, derived by recombinant DNA techniques). The regulation of HuIFN-alpha 2 binding by such pretreatment is reflected by subsequent inhibition of both the antiviral and antiproliferative activities of HuIFN-alpha 2 on T98G cells. Thus, binding of HuIFN-gamma to its distinct cell-surface receptor can modify expression of the separate IFN-alpha receptor, presumably through an indirect effect on the apparent Kd of the IFN-alpha 2 receptor-ligand interaction.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0021-9258
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
259
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
8084-6
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6330099-Burkitt Lymphoma,
pubmed-meshheading:6330099-Cell Line,
pubmed-meshheading:6330099-Encephalomyocarditis virus,
pubmed-meshheading:6330099-Humans,
pubmed-meshheading:6330099-Interferon Type I,
pubmed-meshheading:6330099-Interferon-gamma,
pubmed-meshheading:6330099-Kinetics,
pubmed-meshheading:6330099-Receptors, Cell Surface,
pubmed-meshheading:6330099-Receptors, Interferon
|
pubmed:year |
1984
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pubmed:articleTitle |
Modulation of human interferon-alpha receptor expression by human interferon-gamma.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|