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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1984-8-17
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pubmed:abstractText |
Vitamin D-dependent calcium binding protein (D-CaBP) was localized in the brains of high frequency gymnotid fish. In birds and mammals this protein is seen in a variety of cell types including Purkinje cells, inferior olivary cells and CA1 pyramids of the hippocampus. This distribution has led us to speculate that D-CaBP may be important in buffering intracellular calcium, perhaps more specifically that calcium which enters the cell during dendritic calcium spikes. In the gymnotid fish D-CaBP was found in many of the same cell types in which it is also seen in birds and mammals. In addition, D-CaBP is specifically present in neurons which drive the electric organ (pacemaker and relay cells) and neurons within the electrosensory system which are phase-locked to the electric organ discharge (spherical and giant cells). Relay cells and giant cells have exceptionally high concentrations of D-CaBP. These cells do not exhibit calcium spikes and the role of their D-CaBP may be to regulate calcium released from intracellular stores.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
301
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
166-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6329441-Afferent Pathways,
pubmed-meshheading:6329441-Animals,
pubmed-meshheading:6329441-Calcium,
pubmed-meshheading:6329441-Calcium-Binding Protein, Vitamin D-Dependent,
pubmed-meshheading:6329441-Calcium-Binding Proteins,
pubmed-meshheading:6329441-Cerebellum,
pubmed-meshheading:6329441-Electric Organ,
pubmed-meshheading:6329441-Fishes,
pubmed-meshheading:6329441-Ion Channels,
pubmed-meshheading:6329441-Medulla Oblongata,
pubmed-meshheading:6329441-Mesencephalon,
pubmed-meshheading:6329441-Neurons,
pubmed-meshheading:6329441-Olivary Nucleus,
pubmed-meshheading:6329441-Purkinje Cells,
pubmed-meshheading:6329441-Sensory Receptor Cells,
pubmed-meshheading:6329441-Spinal Cord
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pubmed:year |
1984
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pubmed:articleTitle |
Localization of vitamin D-dependent calcium binding protein in the electrosensory and electromotor system of high frequency gymnotid fish.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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