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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1984-8-7
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pubmed:abstractText |
Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6329430-Animals,
pubmed-meshheading:6329430-Arginine Vasopressin,
pubmed-meshheading:6329430-Male,
pubmed-meshheading:6329430-Medulla Oblongata,
pubmed-meshheading:6329430-Organ Specificity,
pubmed-meshheading:6329430-Oxytocin,
pubmed-meshheading:6329430-Rats,
pubmed-meshheading:6329430-Rats, Inbred Strains,
pubmed-meshheading:6329430-Receptors, Cell Surface,
pubmed-meshheading:6329430-Receptors, Oxytocin,
pubmed-meshheading:6329430-Stimulation, Chemical,
pubmed-meshheading:6329430-Vagus Nerve
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pubmed:year |
1984
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pubmed:articleTitle |
Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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