rdf:type |
|
lifeskim:mentions |
umls-concept:C0000975,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033268,
umls-concept:C0038836,
umls-concept:C0048451,
umls-concept:C0070750,
umls-concept:C0206108,
umls-concept:C0206190,
umls-concept:C1280500,
umls-concept:C1879547
|
pubmed:issue |
2
|
pubmed:dateCreated |
1984-7-12
|
pubmed:abstractText |
A number of gold compounds, nonsteroidal antiinflammatory drugs (NSAID) and protease inhibitors have been examined for their ability to inhibit the respiratory burst of peritoneal macrophages. A potent (IC50 = 5 microM or less) dose dependent inhibitory activity was seen with a number of triethylphosphine gold I ( TEPG ) compounds. Nonphosphine gold compounds were less active. The ligands of TEPG were inactive. Several NSAID stimulated the respiratory burst, whereas 2 protease inhibitors tested were inhibitory. The structure activity relationship of TEPG is also presented.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0315-162X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
11
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
153-7
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:6327980-Animals,
pubmed-meshheading:6327980-Gold,
pubmed-meshheading:6327980-Macrophages,
pubmed-meshheading:6327980-Male,
pubmed-meshheading:6327980-Mice,
pubmed-meshheading:6327980-Mice, Inbred C57BL,
pubmed-meshheading:6327980-Oils,
pubmed-meshheading:6327980-Organogold Compounds,
pubmed-meshheading:6327980-Organometallic Compounds,
pubmed-meshheading:6327980-Peritoneum,
pubmed-meshheading:6327980-Phorbols,
pubmed-meshheading:6327980-Phosphines,
pubmed-meshheading:6327980-Respiration,
pubmed-meshheading:6327980-Structure-Activity Relationship,
pubmed-meshheading:6327980-Superoxides,
pubmed-meshheading:6327980-Tetradecanoylphorbol Acetate
|
pubmed:year |
1984
|
pubmed:articleTitle |
Effect of gold compounds on phorbol myristic acetate (PMA) activated superoxide (O2-) production by mouse peritoneal macrophages.
|
pubmed:publicationType |
Journal Article
|