|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0025677,
umls-concept:C0036525,
umls-concept:C0184511,
umls-concept:C0871261,
umls-concept:C1521828,
umls-concept:C1522484,
umls-concept:C1527249,
umls-concept:C1704632,
umls-concept:C1705294,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1984-7-18
|
|
pubmed:abstractText |
The efficacy of chemotherapy with sequential methotrexate (MTX) and 5-fluorouracil (5-FU) in metastatic colorectal cancer was studied in a multicenter phase II trial using a seven-hour time interval. Forty-two patients were evaluable for response and 16 achieved objective tumor regression (greater than 50%). Median survival of all patients was 12.5 months. The result of this study indicates that MTX and 5-FU are synergistic in human colorectal cancer if given sequentially with a seven-hour time interval. This is supported by a review of the literature that reveals a significantly higher response rate in patients treated with a four-hour or more MTX/5-FU interval as compared to a one-hour interval.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0732-183X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
591-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6327928-Adult,
pubmed-meshheading:6327928-Aged,
pubmed-meshheading:6327928-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:6327928-Bone Neoplasms,
pubmed-meshheading:6327928-Colonic Neoplasms,
pubmed-meshheading:6327928-Drug Administration Schedule,
pubmed-meshheading:6327928-Drug Eruptions,
pubmed-meshheading:6327928-Drug Evaluation,
pubmed-meshheading:6327928-Drug Synergism,
pubmed-meshheading:6327928-Female,
pubmed-meshheading:6327928-Fluorouracil,
pubmed-meshheading:6327928-Humans,
pubmed-meshheading:6327928-Leukopenia,
pubmed-meshheading:6327928-Liver Neoplasms,
pubmed-meshheading:6327928-Lung Neoplasms,
pubmed-meshheading:6327928-Lymphatic Metastasis,
pubmed-meshheading:6327928-Male,
pubmed-meshheading:6327928-Methotrexate,
pubmed-meshheading:6327928-Middle Aged,
pubmed-meshheading:6327928-Peripheral Nervous System Diseases,
pubmed-meshheading:6327928-Rectal Neoplasms
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Sequential methotrexate and 5-fluorouracil: improved response rate in metastatic colorectal cancer.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
