Linked Life Data

6327141

Source:http://linkedlifedata.com/resource/pubmed/id/6327141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-7-13
pubmed:abstractText
The heart rate response to isoprenaline in 11 subjects aged 19-46 years was compared with lymphocyte beta-adrenoceptor numbers and lymphocyte cyclic AMP responsiveness. The dose of isoprenaline required to increase heart rate by 25 beats/min ( CD25 ) increased as a function of age (r 0.79; P less than 0.01). Lymphocyte receptor numbers also correlated directly with age (r 0.61; P less than 0.05), but there was no true correlation between CD25 and lymphocyte receptor numbers. Baseline and maximum lymphocyte cyclic AMP concentrations in response to isoprenaline stimulation in vitro were unrelated to age, CD25 or receptor numbers. This study confirms previous findings of a reduced responsiveness with age and a rise in receptor numbers in young and middle-aged adults. However, the decline in the heart response to isoprenaline was unrelated to any measurable change in beta-adrenoceptor concentration or responses, at least in the isolated lymphocyte.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
697-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Cardiac sensitivity to isoprenaline, lymphocyte beta-adrenoceptors and age.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't