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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1984-5-30
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pubmed:databankReference |
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pubmed:abstractText |
Not all members of the human histone gene family are functional. We have isolated a human H2B pseudogene that contains alterations in the protein-coding sequences as well as in the 3' and 5' flanking sequences that preclude expression of a functional H2B histone protein. There are three modifications in the amino acid-coding region: a single-base deletion producing a frame shift, a single-base substitution resulting in a codon change from serine to tryptophan (an amino acid not present in histones), and the absence of a stop codon. Analysis of nucleotide sequences upstream from the AUG start signal indicates the absence of a "TATA" box and other putative consensus regulatory sequences. In the 3' flanking region, a highly conserved block of 22 nucleotides that exhibits hyphenated dyad symmetry is displaced downstream. Within the same genomic segment, the adjacent H2A histone gene is missing 12 nucleotides, resulting in a deletion of four amino acids in a highly conserved region of the protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-112914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-16591485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-382983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-4919547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-5057976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-5230312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6155216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6159575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6186029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6265100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6274702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6277493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6281786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6296794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6304651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6314274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6446404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6784929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6793234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6801526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-6930668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-7006833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-7070533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-7199388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-7374764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-7407925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-7407926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-954101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6326092-98263
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1936-40
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:6326092-Amino Acid Sequence,
pubmed-meshheading:6326092-Base Sequence,
pubmed-meshheading:6326092-Cloning, Molecular,
pubmed-meshheading:6326092-DNA, Recombinant,
pubmed-meshheading:6326092-DNA Restriction Enzymes,
pubmed-meshheading:6326092-Genes,
pubmed-meshheading:6326092-Histones,
pubmed-meshheading:6326092-Humans,
pubmed-meshheading:6326092-Nucleic Acid Hybridization,
pubmed-meshheading:6326092-Plasmids
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pubmed:year |
1984
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pubmed:articleTitle |
Evidence for a human histone gene cluster containing H2B and H2A pseudogenes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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