Linked Life Data

6324868

Source:http://linkedlifedata.com/resource/pubmed/id/6324868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-6-5
pubmed:abstractText
Several studies have shown that high-density lipoprotein stimulates steroidogenesis in rat tissues which have been treated with pituitary hormones. To determine whether these hormones can directly affect receptors for high-density lipoprotein, we have incubated cultured rat adrenal cortical cells with 125I-labeled human HDL3 and studied the effect of corticotrophin on the binding, internalization and degradation of this lipoprotein. ACTH stimulated all these parameters of HDL metabolism in a dose-dependent manner with maximal stimulation occurring between 10 and 20 mU/ml. The effect was temperature-dependent and showed target cell specificity. Although the hormone stimulated binding and internalization 5-6-fold, degradation of HDL3 was substantially less (2-fold) than anticipated. This suggests that the lipoprotein was taken up by vesicles resembling receptosomes which escape fusion with lysosomes; thus degradation of entrapped particles does not occur, while transfer of cholesterol for steroidogenesis is unaffected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
793
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
180-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The hormonal stimulation of high-density lipoprotein binding, internalization and degradation by cultured rat adrenal cortical cells.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't