Linked Life Data

6323916

Source:http://linkedlifedata.com/resource/pubmed/id/6323916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-5-24
pubmed:abstractText
The epinephrine-induced inotropic effect of the myocardium can be attributed to phosphorylation of the sarcolemmal protein calciductin, as this event is accompanied by a 3.5-fold increase in ATP-independent, voltage-dependent CA2+ uptake by isolated sarcolemmal vesicles. This can be considered as the in vitro equivalent of the Ca2+ slow channel. Ca2+ uptake under these conditions is linear, with the degree of calciductin phosphorylation and inhibitor studies indicate the properties of the unphosphorylated channels are similar to those of the fully activated state. Calciductin has been purified and shows great similarities to phospholamban, a protein modulator of the sarcoplasmic reticulum Ca2+ pump. This raises the interesting possibility that calciductin and phospholamban are identical, although they serve different purposes in the sarcolemma and sarcoplasmic reticulum membranes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0149-046X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-17
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Ca2+-flux modulation by calciductin phosphorylation in cardiac sarcolemma.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't