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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1984-5-18
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pubmed:abstractText |
The FBR murine osteosarcoma virus complex, isolated from a radiation-induced osteosarcoma of an X/Gf mouse causes the rapid appearance of osteosarcomas in newborn mice and transforms fibroblasts in vitro. The two components of the FBR-viral complex have been isolated separately in tissue culture: FBR-MuLV by end-point dilution and FBR-MuSV by the establishment of mouse [FBR-NP 117 (NIH 3T3)] and rat non-producer cell lines [FBR-NP415 (REF)]. The host range and RNase Tl fingerprint analysis of FBR-MuLV demonstrated a pattern closely related to, but distinguishable from, Akv-MuLV. Transformed cells from both mice and rats contain a rescuable FBR-MuSV genome. These pseudotypes produce foci in tissue culture and induce osteosarcomas in susceptible mouse strains. An FBR-MuSV (FBR-MuLV) cDNA probe detects a 5.2 kb HindIII and a 9.5 kb EcoRI FBR-MuSV-specific fragment in FBR-MuSV-transformed non-producer rat cells. The same fragments hybridized with a fos specific probe, demonstrating that FBR-provirus contains a c-fos-derived onc-gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0020-7136
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
511-7
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:6323327-Animals,
pubmed-meshheading:6323327-Base Sequence,
pubmed-meshheading:6323327-Cell Line,
pubmed-meshheading:6323327-Cell Transformation, Viral,
pubmed-meshheading:6323327-DNA, Neoplasm,
pubmed-meshheading:6323327-DNA, Viral,
pubmed-meshheading:6323327-DNA Restriction Enzymes,
pubmed-meshheading:6323327-Deoxyribonuclease EcoRI,
pubmed-meshheading:6323327-Deoxyribonuclease HindIII,
pubmed-meshheading:6323327-Electrophoresis, Agar Gel,
pubmed-meshheading:6323327-Genes, Viral,
pubmed-meshheading:6323327-Leukemia Virus, Murine,
pubmed-meshheading:6323327-Mice,
pubmed-meshheading:6323327-Mice, Inbred AKR,
pubmed-meshheading:6323327-Mice, Inbred BALB C,
pubmed-meshheading:6323327-Oncogenes,
pubmed-meshheading:6323327-Osteosarcoma,
pubmed-meshheading:6323327-Rats,
pubmed-meshheading:6323327-Rats, Inbred Strains,
pubmed-meshheading:6323327-Sarcoma, Experimental,
pubmed-meshheading:6323327-Sarcoma Viruses, Murine
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pubmed:year |
1984
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pubmed:articleTitle |
Characterization of the FBR-murine osteosarcoma virus complex: FBR-MuSV encodes a FOS-derived oncogene.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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