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pubmed:abstractText |
The effects of pro-oxidants (Fe2+, CCl4) and antioxidants (alpha-tocopherol, propyl gallate) on hydroxylation of polycyclic hydrocarbon benz(a)pyrene and on the NADPH-cytochrome P-450-reductase reaction were studied. The role of allyl radicals formed in the fatty acid chains in discussed. The binding of O2 to free radicals, i. e. formation of peroxy radicals, is regarded only as a possible reaction of the radical utilization. It is assumed that other reactions involving lipid radicals, in particular, electron transfer from the flavoprotein to cytochrome P-480 may occur in microsomal membranes.
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