Linked Life Data

6322851

Source:http://linkedlifedata.com/resource/pubmed/id/6322851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-5-17
pubmed:databankReference
pubmed:abstractText
The complete nucleotide sequences of cloned cDNA segments derived from the larval and the adult alpha 1-globin mRNA of Xenopus laevis have been determined. These sequences comprise part of the 5' noncoding region, the entire coding region and the 3' noncoding region, including the polyadenylation site. The larval sequence differs from the adult one by a much longer 3' noncoding region. The sequences diverge by 47%, but codon usage is similar. Comparison of the amino acid sequences of vertebrates shows that the sites of heme contact are highly conserved, whereas the alpha 1/beta 1- and the alpha 1/beta 11-interfaces diverge to different degrees. In these regions the larval alpha 1-globin diverges less from embryonic than from adult alpha-like globins of vertebrates. This suggests that these sites are mainly responsible for the functional peculiarities of the larval amphibian hemoglobins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
781
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-301
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Comparative analysis of the cDNA sequences derived from the larval and the adult alpha 1-globin mRNAs of Xenopus laevis.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't