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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1984-4-11
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pubmed:abstractText |
We have studied the binding of 125I-GF-II to the IM-9 human lymphoid cell line, and to human placental membranes. All of IGF-II radioligand binding to IM-9 cells, and half of the binding to human placental membranes is to a previously unrecognized common (Type-III) high affinity receptor site for insulin-like peptides, in which IGF-I and IGF-II are equipotent and insulin only slightly less potent. This common receptor represents another mechanism by which insulin, and the somatomedins can exert biological action.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
774-82
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:6322765-Binding, Competitive,
pubmed-meshheading:6322765-Cell Line,
pubmed-meshheading:6322765-Female,
pubmed-meshheading:6322765-Humans,
pubmed-meshheading:6322765-Hydrogen-Ion Concentration,
pubmed-meshheading:6322765-Insulin,
pubmed-meshheading:6322765-Kinetics,
pubmed-meshheading:6322765-Lymphocytes,
pubmed-meshheading:6322765-Peptides,
pubmed-meshheading:6322765-Placenta,
pubmed-meshheading:6322765-Pregnancy,
pubmed-meshheading:6322765-Receptors, Cell Surface,
pubmed-meshheading:6322765-Receptors, Somatomedin,
pubmed-meshheading:6322765-Somatomedins
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pubmed:year |
1984
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pubmed:articleTitle |
IGF-II binding on human lymphoid cells: demonstration of a common high affinity receptor for insulin like peptides.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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