Linked Life Data

6322628

Source:http://linkedlifedata.com/resource/pubmed/id/6322628

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-4-6
pubmed:abstractText
Elevated levels of angiotensin-converting enzyme activity (ACE) in bronchoalveolar lavage fluid (BAL) have been used as a specific marker for pulmonary endothelial cell injury associated with high permeability lung edema. Alternatively, however, BAL-ACE elevations might reflect a nonspecific leak of plasma proteins into bronchoalveolar spaces. To investigate the cause of BAL-ACE elevations in high permeability lung injury states, we measured ACE and protein concentrations in BAL from isolated perfused rabbit lungs injured with oleic acid or hyperoxia. Although BAL-ACE was elevated, we found no increase in the BAL-ACE:protein ratio over values from control preparations, despite the presence of marked nonhydrostatic lung edema. We conclude that, in the experimental setting of nonhydrostatic lung edema, BAL-ACE elevations are no more helpful in identifying acute lung injury than are elevated BAL-protein levels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
499-500
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Nonspecificity of elevated angiotensin-converting enzyme activity in bronchoalveolar lavage fluid from high permeability lung edema states.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.